The microglial c-'ASC'-ade hypothesis in Alzheimer's disease and related Tauopathies: Microglial ASC inflammasome activation contributes to tau pathology in vivo Hasselt University
Here we analyze the active role of microgliosis in tau driven pathology to identify novel therapeutic targets for tauopathies including Alzheimer's Disease. The active role of microglia within the pathogenetic process of AD and within the Abeta-Tau-inflammation triad is increasingly pursued as therapeutic target. Highly novel insights in the link between amyloid pathology and microgliosis were previously generated demonstrating (i) the crucial ...