Projects
Attentional deficits and postural alignment: providing new insights in the interaction between cognition and motor function after stroke. University of Antwerp
Remote controlled miniaturized radiotracer injection device for dynamic PET imaging in free running small animals. University of Antwerp
Using molecular proximity to refine synapse quantification in neuronal cultures. University of Antwerp
Transcriptomic profiling of amyloid-induced responses in central and enteric neuronal cultures. University of Antwerp
Characterization of HINT1 knockout Drosophila model for peripheral neuropathy. University of Antwerp
Microglia and neuroinflammation: transducers of amyloid beta toxicity in human Alzheimer’s disease KU Leuven
Alzheimer’s disease (AD) is a chronic neurodegenerative disease and is the most common form of dementia worldwide. AD is characterized by the build up of abnormal protein, in the form of amyloid beta plaques and tau tangles. AD is accompanied by changes in the immune cells of the brain, the microglia. This inflammation in the brain is referred to as neuroinflammation, which may be a simple consequence of damage to nerve cells or may ...
Exploring the role of Aβ, Tau and Tau modulators in inducing neuronal death in a novel humanized mouse model for Alzheimer Disease KU Leuven
Neuronal cell loss is an ultimate hallmark of the many neurodegenerative diseases including Alzheimer’s disease (AD). However, neuronal cell death phenotype is seldom investigated. In AD, the relationship between Amyloid β (Aβ) peptide, Tau, and neuronal death is a central problem. Nevertheless, cell culture or animal models do not reproduce well the cell death phenotype that is crucial to analyze this relation. As it remains unclear to what ...