Projects
Breaking down the wall between human health and environmental testing of endocrine disrupters: EndocRine Guideline Optimisation (ERGO). University of Antwerp
The role of the paraoxonase gene family in obesity and obesity-associated liver disease following exposure to environmental pollutants or medical intervention strategies. University of Antwerp
The role of adipose tissue hypoxia in obesity and obstructive sleep apnea. University of Antwerp
Structural Biology of the Human Androgen Receptor for next generation drug design KU Leuven
The aim of this PhD project is to elucidate the mechanism of action of a novel class of human androgen receptor antagonists (MEL6), which were recently discovered in the KU Leuven Molecular Endocrinology Laboratory. Fragments of the human androgen receptor will be expressed in and purified to high purity from E. coli and utilized for crystallization experiments. While the structures of agonist complexes are already available, all efforts have ...
Unraveling the ligand-independent signaling of the vitamin D receptor KU Leuven
Unraveling the ligand-independent signaling of the vitamin D receptor. The parathyroid hormone (PTH)/vitamin D axis is a major regulator in the maintenance of stable serum calcium concentrations, which is of utmost importance to ensure normal cellular and organ function. Subtle changes in circulating calcium concentrations cause an increase in the secretion of PTH which will, in turn, increase renal calcium reabsorption, enhance calcium ...
The effects of exercise on energy expenditure and muscle function in severe burned patients. University of Antwerp
Mobile monitoring of joint loading profiles in persons with degenerative hip and knee problems Hasselt University
Welcome Trail: improving weight control and CO-morbidities in children with obesity via executive function training. University of Antwerp
Impact of the bacterial colonic metabolism on fecal water toxicity as biomarkers of future colorectal cancer risk after bariatric surgery KU Leuven
Bariatric surgery is an effective way to treat obesity. Roux-en-Y gastric bypass (RYGB) reduces the gastric volume and bypasses parts of the small intestine so that malabsorption is induced whereasSleeve Gastrectomy (SG) only reduces the volume of the stomach without inducing malabsorption. Although bariatric surgery reduces overall cancer risk, evidence indicates that the risk for colorectal cancer (CRC) is increased and might depend on the ...