ADAM17 - A key regulator of microglia polarization after spinal cordinjury Hasselt University
Spinal cord injury (SCI) is characterized by strong post-traumatic inflammation including proinflammatory M1 microglia activation. However, recent studies revealed that activated microglia can also adopt a pro-regenerative phenotype (M2) and improve neural regeneration. Hence, targeting the microglia phenotype M1/M2 switch after SCI is a very promising therapeutic strategy. Preliminary data from our group indicate that "a disintegrin and ...