Projects
Exploring the role of Aβ, Tau and Tau modulators in inducing neuronal death in a novel humanized mouse model for Alzheimer Disease KU Leuven
Neuronal cell loss is an ultimate hallmark of the many neurodegenerative diseases including Alzheimer’s disease (AD). However, neuronal cell death phenotype is seldom investigated. In AD, the relationship between Amyloid β (Aβ) peptide, Tau, and neuronal death is a central problem. Nevertheless, cell culture or animal models do not reproduce well the cell death phenotype that is crucial to analyze this relation. As it remains unclear to what ...
Neurological factors challenging bimanual motor control and treatment response in children with unilateral cerebral palsy Hasselt University
Metabolic editing of the tumor microenvironment as a novel strategy to abate immunosuppression KU Leuven
Cancer immunotherapy has provided patients with a promising treatment approach but also revealed that several tumors rarely exhibit objective responses to these therapies. The harsh tumor microenvironment (TME) along with all his cellular and metabolic crosstalk between cancer and stromal cells is certainly a key player in orchestrating alternative immunosuppressive mechanisms. The next challenge is therefore to identify novel mechanisms and ...