In vitro studies into the downstream regulatory mechanism whereby LRP4 and sclerostin together regulate Wnt siganling activity. University of Antwerp
Previous genetic and functional studies have shown that the canonical Wnt signaling pathway is an important pathway in the regulation of bone formation. The pathway is activated by the binding of Wnt ligands to the receptor complex formed by a Frizzled receptor and an LRP5/6 co-receptor. Furthermore, it is well known that sclerostin is an important inhibitor of the pathway that prevents Wnt ligands from binding to LRP/6 and activating the ...