Exploring the role of DPP6 loss and hyperexcitability in neurodegenerative brain diseases. University of Antwerp
Using advanced genetic and genomic studies, as well as expression studies in brain tissue of patients and electrophysiological modelling in Xenopus laevis oocytes, we identified dipeptidyl peptidase 6 (DPP6) as novel candidate gene in neurodegenerative brain diseases (NBD) (Cacace et al., Journal of Neurochemistry (2016) 138:231-232 and Cacace et al., under revision). Our results suggested a loss-of-function mechanism leading to the ...