Projects
Multi energy simulation and reconstruction (MESRECON). University of Antwerp
Speeded up processing and reconstruction of magnetic resonance images (SUPERMRI). University of Antwerp
Spaceflight induced neuroplasticity studied with advanced magnetic resonance imaging methods (BRAIN-DTI). University of Antwerp
Regulation of the Y-secretase complex and Aß generation during AD by GPR3 KU Leuven
The orphan G protein–coupled receptor (GPCR) GPR3 regulates activity of the γ-secretase complex in the absence of an effect on Notch proteolysis, providing a potential therapeutic target for Alzheimer’s disease (AD). However, given the vast resources required to develop and evaluate any new therapy for AD and the multiple failures involved in translational research, demonstration of the pathophysiological relevance of research findings in ...
A systemic search for novel congenital disorders of Glycosylation type 1 (CDG-I), with a comprehensive evaluation of the clinical phenotypes. KU Leuven
Glycosylation is one of the most abundant protein modifications found in nature. It results from a meticulously orchestrated process involving numerous proteins for the assembly and modification of oligosaccharide chains, and their attachment onto proteins and lipids. The importance of glycosylation is illustrated by a group of diseases called Congenital Disorders of Glycosylation (CDG). To date, almost 100 distinct disorders have been ...
The Role of LRP1 in Tumor Growth and Metastasis. KU Leuven
Gene identification in female patients with intellectual disability and skewed X-inactivation. KU Leuven
Molecular mechanisms of synaptic vesicle rejuvenation: Skywalker and epilepsy KU Leuven
Synapses are often far from their cell bodies and must cope largely independently with dysfunctional proteins resulting from synaptic activity and stress. Protein quality control pathways are involved in the clearance of these dysfunctional proteins, however for some of these pathways, not much is known about their role at synapses. Hence, the main goal of this doctoral thesis is to further inquire into protein quality control at nerve ...
Identifying functional transcriptional targets by next-generation sequencing. KU Leuven
While cancer is unmistakably a genetic disease, it is becoming increasingly apparent that it shares many of its essential characteristics with those typical for developmental processes. Indeed, cancer cells can be considered a potential cell type arising by acquiring specific mutations that alter its regulatory state. Underlying such a cancerous phenotype is a specific gene regulatory network (GRN). In this light, gaining mechanistic insight ...