Identifying functional transcriptional targets by next-generation sequencing. KU Leuven
Laboratory of Computational Biology (VIB-KUÂ Leuven), Laboratory for Molecular Cancer Biology (VIB-KUÂ Leuven)
While cancer is unmistakably a genetic disease, it is becoming increasingly apparent that it shares many of its essential characteristics with those typical for developmental processes. Indeed, cancer cells can be considered a potential cell type arising by acquiring specific mutations that alter its regulatory state. Underlying such a cancerous phenotype is a specific gene regulatory network (GRN). In this light, gaining mechanistic insight ...