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SPEED-XM: SPectral Evaluation and Enhanced Deconvolution by eXtensive (Statistical) Modelling. Hasselt University

A number of key-operations in pharmaceutical development, rely on a correct and timely evaluation of spectral data: e.g, liquid chromatography- mass spectrometry (LC-MS) and solid state Nuclear Magnetic Resonance spectroscopy (ssNMR) are used for compound characterization and MS in a gas-phase setting is used to monitor the headspace of a chemical reactor during the production process of active pharmaceutical ingredients. Nowadays, high amounts ...

Population genomics of freshwater sardines in Central African lakes, and its translation into fisheries policy Hasselt University

Zoology: Biodiversity and Toxicology

Small sardine-like freshwater fishes hold the potential to feed millions of people in the Global South. Yet, the biological mechanisms underlying the adaptation and resilience of these fishes to climate change and fishing pressure are poorly understood. Genetic approaches can provide valuable insights into stock structure, demography and adaptability of fish populations, which can be used to prevent overfishing. Despite the importance of this ...

Implementation of breathomics in health and disease. University of Antwerp

Jan van Meerbeeck

Laboratory Experimental Medicine and Pediatrics (LEMP)

The air we breathe is essential for a healthy live. Health and disease reflect in the exhaled air and already, diseases were linked to its scent. Breath contains both volatile organic compounds (VOCs), and non-volatile components (exhaled breath condensate (EBC), and exhaled particles (PEx)). These include metabolites, signalling molecules and cell constituents which relate to the individual's metabolism and are induced by (patho)fysiological ...

Statistical methods for studying and monitoring biological and industrial processes Ghent University

Stijn Luca

Department of Data analysis and mathematical modelling

Advances in sensor and computing technology are continuously making the acquisition and storage of data more efficient. Statistical modelling and analysis can be used to extract useful insights from data, but are often accompanied with several challenges. In this project, we will develop statistical methods that are generic applicable to study and monitor biological & industrial processes .

Whaleboats in the Forest: Subaltern Technologies of Transportation on Congo’s Inland Waterways KU Leuven

Filip De Boeck

Institute for Anthropological Research in Africa

Congo’s wooden baleinières (Fr. whaleboats) are locally developed and crafted socio-technical assemblages that account for up to 50% of all transportation of goods and people on the waterways of the Congo Basin. Despite the vital role of these subaltern technologies of transportation for the livelihoods of millions, the socio-technical complexities responsible for their success have never been studied. Rooted in older boat building traditions ...

MOde-localized mass Sensors with Thermal Actuation and Piezoresistive DEtection KU Leuven

Michael Kraft

ESAT - MICAS, Microelectronics and Sensors

Micro/nano-electromechanical system (M/NEMS) resonant mass sensors have attracted utmost interest over the past two decades. This is due to their wide range of applications, especially in biochemistry, for instance weighing single molecules, nanoparticles, and even monitoring the growth of living cells. However, their performance is significantly decreased when operated at ambient air and measurements take a considerable time. Therefore, ...

A probabilistic programming approach to the analysis of high-dimensional biological monitoring data. Ghent University

Jan Verwaeren

Department of Data analysis and mathematical modelling

Plant phenotyping studies or studies that monitor of animal or human behavior often rely on the collection and analysis of high-dimensional and (spatio-) temporal datasets. In this research project, probabilistic programming approaches will be developed that allow to incorporate prior knowledge on the study objects (e.g., shape or behavior) into the data analysis pipeline to make the analysis more robust.

Secondary mitral valve regurgitation: hemodynamic and numerical insights towards a patient-tailored approach. Hasselt University

Pieter VANDERVOORT

Health Care

Secondary mitral regurgitation (MR) is a clinical entity with poor prognosis and defective treatment options. Its pathophysiology is grounded on left ventricular (LV) dysfunction or alterations in geometry. Despite the utterly high prevalence of secondary MR, so far no single treatment has been able to prove survival benefit. This may reflect the fact that the underlying mechanics in the pathophysiology of secondary MR are typically ...

RF19/6333 Immunization of broiler breeders to protect broilers against Campylobacter infection Ghent University

An Garmyn

Department of Pathology, bacteriology and poultry diseases

Campylobacter is the most common cause of foodborne bacterium-mediated diarrheal disease in humans worldwide. Broiler chickens are a natural host for this pathogen and their carcasses often become contaminated during slaughter, making poultry products the most significant source for campylobacteriosis in humans.

Interestingly, chickens are only colonized from the age of two to three weeks, due to the protection by maternal IgY ...

Pathophysiological relevance of the cholesterol regulation of the chemosensory channel TRPA1 KU Leuven

Karel Talavera Pérez

Laboratory of Ion Channel Research (VIB-KU Leuven Center for Brain & Disease Research)

Obesity and related health risks such as developing a cardiovascular disease become a significant public health problem causing thousands deaths annually. Associated with these diseases hypercholesterolemia and hyperlipidemia are commonly treated with statins. However, these cholesterol-lowering drugs do not only block cholesterol synthesis in the liver but in all cells of the body. This induces serious side effects such as neuropathy affecting ...

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