Manipulating Wnk kinase function as a therapeutic application in neurological diseases KU Leuven
Wnk is an essential kinase, found to be misregulated in different diseases such as hypertension, cancers and neuropathies. However, Wnk has only been extensively studied in renal tissue, where it regulates chloride homeostasis, and not much is known of Wnk function in other tissues. We recently discovered that loss of Wnk kinase in Drosophila sensory neurons results in axonal branching defects and axon degeneration. Loss of Wnk in ...