Publications
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The FMRP regulon: from targets to disease convergence KU Leuven
The fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates mRNA metabolism. FMRP has been largely studied in the brain, where the absence of this protein leads to fragile X syndrome, the most frequent form of inherited intellectual disability. Since the identification of the FMRP gene in 1991, many studies have primarily focused on understanding the function/s of this protein. Hundreds of potential FMRP mRNA targets ...
Stability studies of phosphoramidate nucleosides KU Leuven
Phosphoramidate nucleotides (as conjugates between nucleoside monophosphate and amino acids) have been developed as potential antiviral/antitumoral prodrugs and, recently, have been evaluated as substrate for polymerases. Despite of these intensive chemical and biological investigations, carried out with phosphoramidate nucleotides, little is known about their chemical stability and the influence of the nucleobase on the kinetics of the ...