Publications
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CLASSICAL PATHWAY ACTIVATION IN A PATIENT WITH LIGHT CHAIN DEPOSITION DISEASE AND ANGIOEDEMA KU Leuven
FUNCTIONAL CHARACTERIZATION OF COMPLEMENT C2 MUTANTS IDENTIFIED IN PATIENTS WITH GLOMERULOPATHIES KU Leuven
Plasmodium berghei NK65 in combination with IFN-γ induces endothelial glucocorticoid resistance via sustained activation of p38 and JNK KU Leuven
Malaria-associated acute respiratory distress syndrome (MA-ARDS) is an often lethal complication of malaria. Currently, no adequate therapy for this syndrome exists. Although glucocorticoids (GCs) have been used to improve clinical outcome of ARDS, their therapeutic benefits remain unclear. We previously developed a mouse model of MA-ARDS, in which dexamethasone treatment revealed GC resistance. In the present study, we investigated GC ...
CD36 deficiency blunts effects of diet on regulatory T cells in murine gonadal adipose tissue and mesenteric lymph nodes KU Leuven
The effect of cluster of differentiation (CD)36 on regulatory T cells (Treg) was investigated in gonadal (GN) adipose tissues and mesenteric lymph nodes (MLN) of wild-type (WT) and CD36 deficient (CD36−/−) mice kept on standard fat (SFD, lean) or on high fat diet (HFD, obese). GN adipose tissue mass was smaller, but MLN size larger for obese CD36−/− versus obese WT mice. Overall, the reduction of Treg cells in GN adipose tissue and MLN after a ...