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A baseline for skeletal investigations in medaka (Oryzias latipes) : the effects of rearing density on the postcranial phenotype Ghent University
Oryzias latipes is increasingly used as a model in biomedical skeletal research. The standard approach is to generate genetic variants with particular skeletal phenotypes which resemble skeletal diseases in humans. The proper diagnosis of skeletal variation is key for this type of research. However, even laboratory rearing conditions can alter skeletal phenotypes. The subject of this study is the link between skeletal phenotypes and rearing ...
More healthy bone : alternating dietary phosphorus increases bone volume in zebrafish Ghent University
Compression fractures and partial phenotype rescue with a low phosphorus diet in the chihuahua zebrafish osteogenesis imperfecta model Ghent University
Osteogenesis imperfecta (OI) is a group of heritable disorders affecting bone and other connective tissues. Dominant OI forms are mainly caused by mutations in collagen type I. Patients suffer from skeletal deformities, fractures of long bones and vertebral compression fractures from early childhood onward. Altered collagen structure and excess mineralisation are the main causes for the bone phenotype. The Chihuahua (Chi/+) zebrafish has become ...
More bone with less minerals : the effects of dietary phosphorus on the zebrafish skeleton Ghent University
Single-cell transcriptomes and runx2b(−/−) mutants reveal the genetic signatures of intermuscular bone formation in zebrafish Ghent University
Intermuscular bones (IBs) are mineralized spicules, present in the myosepta of many, but not all, teleost species. IBs are often small and sharp, and they consequently limit how the fish can be processed; the IBs may cause injury or trauma if lodged in consumers' throats or mouths, and therefore affect the appeal of the fish to many consumers. The development of IBs in teleosts is still not fully understood and the molecular basis of IB ...
The conundrum of pharyngeal teeth origin : the role of germ layers, pouches, and gill slits Ghent University
Seadragon genome analysis provides insights into its phenotype and sex determination locus Ghent University
The iconic phenotype of seadragons includes leaf-like appendages, a toothless tubular mouth, and male pregnancy involving incubation of fertilized eggs on an open "brood patch." We de novo-sequenced male and female genomes of the common seadragon (Phyllopteryx taeniolatus) and its closely related species, the alligator pipefish (Syngnathoides biaculeatus). Transcription profiles from an evolutionary novelty, the leaf-like appendages, show that a ...