Publications
COVID-19-related health utility values and changes in COVID-19 patients and the general population University of Antwerp
Purpose To summarise the diverse literature reporting the impact of COVID-19 on health utility in COVID-19 patients as well as in general populations being affected by COVID-19 control policies. Methods A literature search up to April 2023 was conducted to identify papers reporting health utility in COVID-19 patients or in COVID-19-affected general populations. We present a narrative synthesis of the health utility values/losses of the retained ...
Training of epitope-TCR prediction models with healthy donor-derived cancer-specific T cells University of Antwerp
Discovery of epitope-specific T-cell receptors (TCRs) for cancer therapies is a time consuming and expensive procedure that usually requires a large amount of patient cells. To maximize information from and minimize the need of precious samples in cancer research, prediction models have been developed to identify in silico epitope-specific TCRs. In this chapter, we provide a step-by-step protocol to train a prediction model using the ...
Multimorbidity healthcare expenditure in Belgium University of Antwerp
Background The complex management of health needs in multimorbid patients, alongside limited cost data, presents challenges in developing cost-effective patient-care pathways. We estimated the costs of managing 171 dyads and 969 triads in Belgium, taking into account the influence of morbidity interactions on costs. Methods We followed a retrospective longitudinal study design, using the linked Belgian Health Interview Survey 2018 and the ...
Longitudinal social contact data analysis University of Antwerp Hasselt University KU Leuven
Background During the COVID-19 pandemic, the CoMix study, a longitudinal behavioral survey, was designed to monitor social contacts and public awareness in multiple countries, including Belgium. As a longitudinal survey, it is vulnerable to participants'"survey fatigue", which may impact inferences. Methods A negative binomial generalized additive model for location, scale, and shape (NBI GAMLSS) was adopted to estimate the number of contacts ...
Assessing the impact of COVID-19 passes and mandates on disease transmission, vaccination intention, and uptake University of Antwerp Hasselt University KU Leuven
PurposePolicymakers have struggled to maintain SARS-CoV-2 transmission at levels that are manageable to contain the COVID-19 disease burden while enabling a maximum of societal and economic activities. One of the tools that have been used to facilitate this is the so-called "COVID-19 pass". We aimed to document current evidence on the effectiveness of COVID-19 passes, distinguishing their indirect effects by improving vaccination intention and ...
The administration of methotrexate in patients with Still's disease, "real-life" findings from AIDA Network Still Disease Registry University of Antwerp
Objectives: To describe clinical characteristics of patients with Still's disease treated with methotrexate (MTX) and to assess drug effectiveness evaluating change in disease activity, reduction of inflammatory markers, and glucocorticoid (GC)-sparing effect. Methods: Patients with Still's disease treated with MTX were assessed among those included in AIDA Network Still Disease Registry.Results: In this registry, 171 patients with Still's ...
Clinical and laboratory features associated with macrophage activation syndrome in Still's disease: data from the international AIDA Network Still's Disease Registry (vol 18, pg 2231, 2023) University of Antwerp
Cost-effectiveness of respiratory syncytial virus preventive interventions in children University of Antwerp
Objectives: Model-based cost-effectiveness analyses on maternal vaccine (MV) and monoclonal antibody (mAb) interventions against respiratory syncytial virus (RSV) use context-specific data and produce varied results. Through model comparison, we aim to characterize RSV cost-effectiveness models and examine drivers for their outputs.Methods: We compared 3 static and 2 dynamic models using a common input parameter set for a hypothetical birth ...
Investigating confounding in network-based test-negative design influenza vaccine effectiveness studies University of Antwerp
Background: Establishing a large study network to conduct influenza vaccine effectiveness (IVE) studies while collecting appropriate variables to account for potential bias is important; the most relevant variables should be prioritized. We explored the impact of potential confounders on IVE in the DRIVE multi-country network of sites conducting test-negative design (TND) studies.Methods: We constructed a directed acyclic graph (DAG) to map the ...