Combining experimental and computational approaches to investigate arrhythmogenic consequences of connexin hemichannel opening in the heart. Ghent University
The project starts with the in depth characterization of Cx43 hemichannels as channels commanded by
voltage, intracellular Ca2+ and mechanical forces (WP1). These data will be incorporated into an existing and
well acknowledged multi-scale model of the heart aiming to predict the effects of hemichannel opening on three
well chosen arrhythmia conditions described in WP2, WP3 & WP4. In these WPs, we test the ...