Is neuroinflammation a mediator of the sleep-pain relationship? Unravelling the role of microglia in insomnia & chronic low back pain KU Leuven
Chronic low back pain (CLBP) is the world-leading cause of pain and disability, but the aetiology remains largely unknown. Intriguingly, aberrant glial activation has emerged as a novel yet plausible mediator of the increased sensitivity within the central nervous system observed among chronic pain patients. Furthermore, pre-clinical studies support the role of glial activation in sleep deprivation, and insomnia represent a major comorbidity ...