Projects
Muscle fiber type composition in elite field-based team sports; a translation from the lab to the pitch Ghent University
The gut-brain axis, nutrition and drug-resistant idiopathic epilepsy in dogs: Is there a role for the manipulation of the gut-microbiome and metabolome? Ghent University
A Single-Cell Omics Exploration of the Molecular Arms Race Underlying Tomato Arbuscular Mycorrhizal Symbiosis. Ghent University
The diaspora kino-eye: A multi-methodological research project on diaspora film policies and representations in Flanders (2002-2021) Ghent University
A novel non cell-autonomous plant growth stimulatory molecule: its nature, regulation and applications Ghent University
Phenotypic plasticity of cell polarization and rhizoid growth in early development of Dictyota dichotoma Ghent University
Furan and porphyrin containing crosslinking ligands for covalent stabilisation of G quadruplexes as cell-permeable anti-cancer aptamers Ghent University
Using a variety established DNA crosslinking nucleobase-analogues a method will be developed for the stapling of the 5’ and 3’ ends of G-quadruplex forming aptamer sequences. This staple will in theory convey several benefits such as conformational locking and improved formation kinetics. Crosslinked aptamers will then be assessed for improvements in these properties compared to wild type oligonucleotides.
Antibody-oligonucleotide conjugation for cellular delivery of oligonucleotides Ghent University
We herein propose the usage of a novel bioconjugation methodology to exploit antibody analogues (Ab) as delivery vehicles for oligonucleotide therapeutics (ON) to overcome current limits regarding ON specificity and potency. Novel therapeutically relevant Ab-ON conjugates will be synthesised, characterised, and biologically evaluated which potentially leads to a novel platform technology, which could be applied to other ONs.