ACTIVATION OF RAS BY A FRUCTOSE-1,6-BISPHOSPHATE / GUANINE NUCLEOTIDE EXCHANGE PROTEIN COMPLEX KU Leuven
The present invention relates to an isolated fructose-1,6-bisphosphate / SOS complex. The invention relates further to the use of the complex to screen for compounds that modulate the activation of Ras, and the use of yeast strains for said screening. The invention relates also to compounds, disrupting the fructose-1,6-bisphosphate / SOS complex and the use of such compounds in the treatment of cancer.