Optimized AAV systems for vectored immunoprophylaxis as a therapeutic strategy to treat CNS related diseases KU Leuven
Alzheimer's Disease (AD) is the most common form of dementia worldwide. Being a progressive disease, memory loss and cognitive decline worsen over time and ultimately lead to death. The causes of the disease are not well understood to date. Evidences suggest that the accumulation of amyloid plaques, composed of amyloid beta peptide (Abeta), in the brain is central to the disease pathology. Abeta is formed by the activity of beta and gamma ...