How risk genes of late-onset Alzheimer’s disease contribute to the outset of lysosomal homeostasis impairment in neurons at early stages of the neuropathogenic cascade: the case of PLD3. KU Leuven
Phospholipase D3 (PLD3) is a brain-expressed protein of which the cellular functions remain to be elucidated. Nevertheless, PLD3 was identified in genetic studies as a risk factor for the development of late-onset Alzheimer’s disease, by far the most frequent form of dementia. PLD3 is localized in degradative compartments of neurons that are known to be malfunctioning in early disease stages and to be involved in the aggregation of toxic ...