Therapeutic targeting of pathogenic presynaptic Tau in human neurons in a chimeric Alzheimer’s Disease mouse model KU Leuven
Alzheimer’s disease is a progressive neurodegenerative disorder, and is characterized by amyloid beta plaques, neurofibrillary tangles and granulovacuolar degeneration (Scheltens et al. 2021). An early deficit in AD is synaptic dysfunction, which closely correlates to cognitive decline (Dekosey et al. 1990; Terry et al. 1991). Tau pathology plays a causal role in synaptic dysfunction (Zhou et al. 2017; Mclnnes et al. 2018) as it binds to ...