Systemic evaluation of microRNA-132 as a therapeutic target in Alzheimer's disease. KU Leuven
Previous work has shown that microRNA profiles in the brains of Alzheimer’s disease (AD) patients change with the progression of the pathology, suggesting a possible role for microRNAs in AD. Of particular interest is the brain-enriched microRNA-132 (miR-132), whose levels are significantly and robustly decreased in AD patient brain. Moreover, this microRNA has been associated with several molecular pathways that are also affected in AD, such ...