Making bacteria antibiotic-sensitive again: Towards understanding the genetic and physiological basis of persister cell awakening KU Leuven
A major cause of antibiotic therapy failure and the chronic nature of bacterial infections is a small fraction of transiently tolerant cells called persisters. These cells can survive antibiotic treatment and resume growth when the antibiotic pressure drops. Despite the threats posed by persisters, a thorough understanding of persistence in clinical and natural strains is still lacking and knowledge on how cells revert from the persistent ...