Role of Presenilin2 deficiency and familial Alzheimer's disease mutants in intracellular Abeta accumulation and Alzheimer's disease pathology KU Leuven
Alzheimer’s disease (AD) is characterized by the progressive build-up of amyloid-beta (AB) in plaques. gamma-Secretase processing releases AB from the amyloid precursor protein and comes in different flavours because of the existence of two presenilins and APH1 isoforms. Distinct complexes generate slightly different AB profiles and familial AD linked mutations in PSENs shift the production to longer AB species which aggregate more easily. ...