Projects
Evaluative learning via analogy Ghent University
Evaluation – liking and disliking – is central to everyday psychological life. Our evaluations of individuals, groups, objects, activities, and concepts shape how we interact with the world. This ubiquity demands that we understand how, when and why evaluations can be established and changed.
The field of learning psychology has studied how arranging the environment in specific ways influences evaluations. For example, repeated exposure ...
Valorisation of 8-PN analogs - synthetic analogues of the powerful phytoestrogen from hops Ghent University
Synthesis and evaluation of microcin C analogs as aminoacyl-tRNA synthetase inhibitors. KU Leuven
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Synthesis of sugar-modified alpha-galactosylceramide analogs as Th1-polarizing NKT-cell antigens Ghent University
Synthesis of sugar and sphingosine modified alpha-galactosylceramide (KRN 7000) analogues as NKT cell agonists capable of inducing a Th1-polarised cytokine response. The proposed modifications intend to establish an improved binding affinity to the antigenpresenting CD1d protein, which should result in a bias towards a Th1 respons, as well as an improved aqueous solubility.
Design and design automation of analog and mixed-signal integrated circuits KU Leuven
Microelectronic/nanoelectronic integrated circuits are the underlying technology for the many ICT applications that increasingly impact our daily lives: computing, communication, multimedia, entertainment, transport, healthcare, etc. While more and more applications are becoming digital in nature, analog and mixed analog-digital integrated circuits remain an essential part in electronic systems for the countless applications that interact ...
Vitamin D analogs in combination with palbociclib as treatment for triple-negative breast cancer – preclinical evaluation and pathway analysis KU Leuven
1,25(OH)2D3, the biological active form of vitamin D3, is an important regulator of calcium and phosphate homeostasis in the body. By binding to the vitamin D receptor (VDR) and subsequent heterodimerization with the retinoid X receptor (RXR), this complex will migrate to the nucleus and bind to vitamin D responsive elements (VDREs) in regulatory regions of target genes to regulate gene transcription. Next to calcium and phosphate ...
Structure-based design of ribonucleoside triphosphate (rNTP) analogs targeting bacterial RNA polymerases KU Leuven
The role of the 1,25(OH)2D3 signaling cascade and its analogs on inflammatory bowel disease KU Leuven
Inflammatory bowel disease (IBD) represents a group of idiopathic, chronic diseases of the gastro-intestinal tract including both Crohn’s disease (CD) and ulcerative colitis (UC). The exact etiology of IBD is still largely unknown, however, it is generally accepted that an excessive host immune response towards luminal bacteria plays a major role. A genetic predisposition, environmental factors as well as the epithelial barrier itself ...
Explorations in quinoline chemistry – towards the development of novel piperidine-quinoline hybrids with antimalarial activity and nitroxoline analogs with anti-tumor activity Ghent University
Quinolines are privileged scaffolds in medicinal chemistry because of the broad diversity of biological activities associated with these heterocyclic compounds. Two major fields to which quinoline chemistry is expected to contribute significantly in the future concern antimalarial studies and anticancer research. Thus, the current project aims at the synthesis of novel piperidine-quinoline hybrids with antimalarial activity and nitroxoline ...