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Generic semi-automated radiofluorination strategy for single domain antibodies: [18F]FB-labelled single domain antibodies for PET imaging of fibroblast activation protein-α or folate receptor-α overexpression in cancer Vrije Universiteit Brussel

Herlinde Dierick, Laurent Navarro, Hannelore Ceuppens, Thomas Ertveldt, Ana Rita Pombo Antunes, Marleen Keyaerts, Nick Devoogdt, Karine Breckpot, Matthias D'Huyvetter, Tony Lahoutte, et al.

BACKGROUND: Radiofluorination of single domain antibodies (sdAbs) via N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) has shown to be a promising strategy in the development of sdAb-based PET tracers. While automation of the prosthetic group (PG) [18F]SFB production, has been successfully reported, no practical method for large scale sdAb labelling has been reported. Therefore, we optimized and automated the PG production, enabling a ...

HER2-directed antibodies, affibodies and nanobodies as drug-delivery vehicles in breast cancer with a specific focus on radioimmunotherapy and radioimmunoimaging KU Leuven

Betuel Altunay, Agnieszka Morgenroth, Mohsen Beheshti, Andreas Vogg, Nicholas CL Wong, Hong Hoi Ting, Hans-Juergen Biersack, Elmar Stickeler, Felix Mottaghy
PURPOSE: The aim of the present paper is to review the role of HER2 antibodies, affibodies and nanobodies as vehicles for imaging and therapy approaches in breast cancer, including a detailed look at recent clinical data from antibody drug conjugates and nanobodies as well as affibodies that are currently under development. RESULTS: Clinical and preclinical studies have shown that the use of monoclonal antibodies in molecular imaging is impaired ...

Added value of antiphosphatidylserine/prothrombin antibodies in the workup of thrombotic antiphospholipid syndrome : communication from the ISTH SSC subcommittee on lupus anticoagulant/antiphospholipid antibodies Ghent University

Arne Vandevelde, Walid Chayoua, Bas de Laat, Gary W. Moore, Jacek Musial, Stéphane Zuily, Denis Wahl, Katrien Devreese
Background Diagnosis of antiphospholipid syndrome (APS) requires persistent presence of lupus anticoagulant (LAC), anticardiolipin (aCL) IgG/IgM, or anti-beta 2 glycoprotein I (a beta 2GPI) IgG/IgM antibodies. Other antiphospholipid antibodies (aPL) such as antiphosphatidylserine/prothrombin antibodies (aPS/PT) are promising in assessment of thrombotic APS (TAPS). Aim To evaluate the added value of aPS/PT IgG and IgM in TAPS. Material and ...

Semiquantitative interpretation of anticardiolipin and antiβ2glycoprotein I antibodies measured with various analytical platforms : communication from the ISTH SSC subcommittee on lupus anticoagulant/antiphospholipid antibodies Ghent University

Arne Vandevelde, Walid Chayoua, Bas de Laat, JeanU+2010Christophe Gris, Gary W. Moore, Jacek Musial, Stéphane Zuily, Denis Wahl, Katrien Devreese
Background Anti beta 2glycoprotein I (a beta 2GPI) and anticardiolipin (aCL) IgG/IgM show differences in positive/negative agreement and titers between solid phase platforms. Method-specific semiquantitative categorization of titers could improve and harmonize the interpretation across platforms. Aim To evaluate the traditional 40/80-unit thresholds used for aCL and a beta 2GPI for categorization into moderate/high positivity with different ...

Relative seroprevalence of cysticercus antigens and antibodies and antibodies to Taenia ova in a population sample in south India suggests immunity against neurocysticercosis Institute of Tropical Medicine

T Jayaraman, V Prabhakaran, P Babu, MV Raghava, V Rajshekhar, Pierre Dorny, J Muliyil, A Oommen
We evaluated the exposure of a community in Vellore district of south India to Taenia solium infection and its relationship to the prevalence of neurocysticercosis (NCC) causing active epilepsy. Seroprevalence of Taenia cysticercus antigens and antibodies were determined in 1064 randomly chosen asymptomatic individuals, antibodies to T. solium ova in 197 selected sera, and prevalence of taeniasis by a coproantigen test in 729 stool samples. The ...

Incidence, prevention and management of anti-drug antibodies against therapeutic antibodies in inflammatory bowel disease : a practical overview Ghent University

Pieter Hindryckx, Gregor Novak, Niels Vande Casteele, Reena Khanna, Debby Laukens, Jairath Vipul, Brian G Feagan
The introduction of biologic therapy has revolutionized the treatment of inflammatory bowel disease (IBD). However, like all therapeutic proteins, monoclonal antibodies have immunogenic potential which is influenced by multiple drug- and patient-related factors. The reported incidence of anti-drug antibodies (ADAs) towards biologic drugs in IBD varies greatly in the literature and depends not only on differences in sensitization but also on the ...

Added value of antiphosphatidylserine/prothrombin antibodies in the workup of obstetric antiphospholipid syndrome : communication from the ISTH SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies Ghent University

Arne Vandevelde, Jean-Christophe Gris, Gary W. Moore, Jacek Musiał, Stéphane Zuily, Denis Wahl, Katrien Devreese
Background: The added value of antiphosphatidylserine/prothrombin antibodies (aPS/ PT) in the diagnostic workup of antiphospholipid syndrome (APS) is unclear. Currently, diagnosis of thrombotic APS (TAPS) and obstetric APS (OAPS) requires persistent presence of lupus anticoagulant (LAC), anticardiolipin (aCL) immunoglobulin (Ig) G/IgM, or anti-beta 2- glycoprotein I (a beta 2GPI) IgG/IgM antibodies. Objectives: To evaluate the role of aPS/PT IgG ...

Laboratory testing for non-criteria antiphospholipid antibodies : antibodies toward the domain I of beta2-glycoprotein I (aDI) Ghent University

Katrien Devreese
Anti-β2GPI antibodies (aβ2GPI) are one of the laboratory criteria for antiphospholipid syndrome (APS), along with lupus anticoagulant (LA) and anticardiolipin antibodies (aCL). A subset of the aβ2GPI are the antibodies directed toward the domain I of the β2GPI (aDI). The aDI are regarded as non-criteria aPL and are among the most studied non-criteria aPL. Antibodies directed against a specific epitope in the domain I (G40-R43) of β2GPI were ...

Laboratory testing for non-criteria antiphospholipid antibodies : anti-phosphatidylserine/prothrombin antibodies (aPS/PT) Ghent University

Katrien Devreese
Since the discovery that antiphospholipid antibodies (aPL) bind to a cofactor at the phospholipid membrane, the proteins beta-2-glycoprotein I (β2GPI) and prothrombin seemed to be the antigens of importance in the antiphospholipid syndrome (APS). Anti-β2GPI antibodies (aβ2GPI) were soon included in the classification criteria, while anti-prothrombin antibodies (aPT) are still regarded as “non-criteria” aPL. Evidence is accumulating that ...