Publications
Memory CD4(+)CD127(high) T cells from patients with multiple sclerosis produce IL-17 in response to myelin antigens Hasselt University Ghent University
Epitope and HLA-type independent monitoring of antigen-specific T-cells after treatment with dendritic cells presenting full-length tumor antigens KU Leuven
Treatment with egg antigens of Schistosoma mansoni ameliorates experimental colitis in mice through a colonic T-celldependent mechanism University of Antwerp
IRAK-4 and MyD88 deficiencies impair IgM responses against T-independent bacterial antigens KU Leuven
Expression of activation antigens, HLA-DR and CD38, on CD8 lymphocytes during HIV-1 infection Institute of Tropical Medicine
Host Th1/Th2 immune response to Taenia solium cyst antigens in relation to cyst burden of neurocysticercosis Institute of Tropical Medicine Ghent University
Neurocysticercosis, Taenia solium larval infection of the brain, is an important cause of acquired seizures in endemic countries which relate to number, location and degenerating cysts in the brain. Multi-cyst infections are common in endemic countries although single cyst infection prevail in India. Single cyst infections in an endemic country suggest a role for host immunity limiting the infection. This study examined ex vivo CD4(+) T cells ...
HP-1γ Controls High-Affinity Antibody Response to T-Dependent Antigens KU Leuven
Bacterial CD1d-restricted glycolipids induce IL-10 production by human regulatory T cells upon cross-talk with invariant NKT cells Vrije Universiteit Brussel Ghent University
Invariant NKT (iNKT) cells and CD4(+)CD25(+)FOXP3(+) regulatory T cells (Tregs) are important immune regulatory T cells with Ag reactivity to glycolipids and peptides, respectively. However, the functional interplay between these cells in humans is poorly understood. We show that Tregs suppress iNKT cell proliferation induced by CD1d-restricted glycolipids, including bacterial-derived diacylglycerols, as well as by innate-like activation. ...
Label-free phenotyping of peripheral blood lymphocytes by infrared imaging Vrije Universiteit Brussel
It is now widely accepted that the immune microenvironment of tumors and more precisely Tumor Infiltrating Lymphocytes (TIL) play an important role in cancer development and outcome. TILs are considered to be important prognostic and predictive factors based on a growing body of clinical evidence; however, their presence at the tumor site is not currently assessed routinely. FTIR (Fourier transform infrared) imaging has proven it has value in ...