Beyond optimising drug exposure: Pharmacodynamic models to bridge the gap between exposure and response to antimicrobial treatments KU Leuven
Dosage regimens are based on randomised controlled trials that usually do not represent the heterogeneity of the final intended real-world treatment population well. Real-world variability in drug exposure is common and can result in suboptimal treatment. To hit a predefined exposure target in each patient, pharmacokinetic (PK) monitoring can be implemented. PK monitoring facilitates the attainment of a desired exposure target by guiding ...