Perturbation of extracellular matrix (ECM)-degrading cellulair devices by means of photoporation-directed nanobody delivery in immune cells and cancer cells. Ghent University
This project will investigate a particular intracellular structure that is found in immune cells, osteoclasts and cancer cells. It consists of many different proteins that together build up a so-called invadopodium. This is a sort of molecular tiny foot or 'drill' that makes holes in the underlying basement membrane. This allows immune cells to engage pathogens that are hidden somewhere in tissues, but also allows cancer cells to escape from ...