Projects
Diagnosis of pneumonia in critically ill patients using real-time bedside breath analysis. University of Antwerp
A sensor based breath analysing device. KU Leuven
We have developed a chemo-optical sensor platform that might fulfil the requirements of the ideal breath analysing device for Point-Of-Care Testing (POCT). Breath analysis is emerging as a valuable non-invasive clinical diagnostic tool. The cornerstone of our technology is the use of atomic layer deposition engineered nanoporous films. We have protected this innovative approach by two patent applications. The objective of GALE is to develop ...
BREAZE - BREath analyser with ALD coated ZEolite Ghent University
a chemo-optical sensor platform that might fulfil the requirements of the ideal breath analysing device for Point-Of-Care Testing (POCT)
Invasive pulmonary aspergillosis: biomarkers in exhaled breath condensate for early diagnosis and diversity of pathogens involved. KU Leuven
In vivo analysis of the role of a newly identified screenings hit in breast epithelial homeostasis and basal breast cancer progression Ghent University
The hit was identified in an siRNA screen as being crucial in ZEB-1 mediated EMT. Transcription factors essential in normal development play an important role in this process. Moreover, studies have shown that EMT is linked with (cancer)stem cells. This suggests an important function for our hit in normal breast development and the progression of basal breast cancer.
Vitamin D analogs in combination with palbociclib as treatment for triple-negative breast cancer – preclinical evaluation and pathway analysis KU Leuven
1,25(OH)2D3, the biological active form of vitamin D3, is an important regulator of calcium and phosphate homeostasis in the body. By binding to the vitamin D receptor (VDR) and subsequent heterodimerization with the retinoid X receptor (RXR), this complex will migrate to the nucleus and bind to vitamin D responsive elements (VDREs) in regulatory regions of target genes to regulate gene transcription. Next to calcium and phosphate ...
Analysis of chromosomal radiosensitivity/instability in triple negative and/or young breast cancer patients and patients with Fanconi anemia from South Africa Ghent University
Chromosomal radiosensitivity has been observed in breast cancer patients in European populations and is linked with DNA repair pathways. As triple negative, young breast cancer and Fanconi anemia patients frequently have defects in these pathways , the chromosomal radiosensitivity, instability and the link with DNA repair genes will be investigated in these patients.
Development of a new point-of-care COVID-19 screening using exhaled-breath volatilome analysis. KU Leuven
BACKGROUND: The inability to rapidly detect SARS-CoV-2 infection during the COVID-19 pandemic inspired strict lockdown policies, resulting in unprecedented economic adversity and clogging the health care sys-tem. As countries’ fears for second and third wave outbreaks are becoming reality, there is an urgent need for globally available, easy-to-perform, non-invasive, on-the-spot diagnostic tests to detect SARS-CoV-2 and to predict COVID-19 ...