Publications
Argumenten en patiënten; het theorema van Bayes Institute of Tropical Medicine
BFpack : flexible bayes factor testing of scientific theories in R Ghent University
There have been considerable methodological developments of Bayes factors for hypothesis testing in the social and behavioral sciences, and related fields. This development is due to the flexibility of the Bayes factor for testing multiple hypotheses simultaneously, the ability to test complex hypotheses involving equality as well as order constraints on the parameters of interest, and the interpretability of the outcome as the weight of ...
Prior sensitivity in theory testing: An apologia for the Bayes factor KU Leuven
A commonly voiced concern with the Bayes factor is that unlike many other Bayesian and non-Bayesian quantitative measures of model evaluation it is highly sensitive to the parameter prior This paper argues that when dealing with psychological models that are quantitatively instantiated theories being sensitive to the prior is an attractive feature of a model evaluation measure This assertion follows from the observation that in psychological ...
Bayes and diagnostic testing Institute of Tropical Medicine
Halogen Bonding from a Hard and Soft Acids and Bases Perspective: Investigation by Using Density Functional Theory Reactivity Indices Vrije Universiteit Brussel
Halogen bonds between the trifluoromethyl halides CF3Cl, CF3Br and CF3I, and dimethyl ether, dimethyl sulfide, trimethylamine and trimethyl phosphine were investigated using Pearson's hard and soft acids and bases (HSAB) concept with conceptual DFT reactivity indices, the Ziegler-Rauk-type energy-decomposition analysis, the natural orbital for chemical valence (NOCV) framework and the non-covalent interaction (NCI) index. It is found that the ...
Le néopythagorisme, les Baals syriens et les divinités planétaires. Les théories de Cumont et le cas de la Vie d’Apollonius de Tyane Ghent University
This paper discusses the theories of Franz Cumont on the influence of Stoics and Neopythagoreans on the diffusion of astrology and the emergence of astral mysticism in the Roman world and links this to a new religious and philosophical interpretation of the Life of Apollonius of Tyana.
Decision-making in the diagnosis of tuberculous meningitis Institute of Tropical Medicine
Tuberculous meningitis (TBM) is the most devastating form of tuberculosis (TB) but diagnosis is difficult and delays in initiating therapy increase mortality. All currently available tests are imperfect; culture of Mycobacterium tuberculosis from the cerebrospinal fluid (CSF) is considered the most accurate test but is often negative, even when disease is present, and takes too long to be useful for immediate decision making. Rapid tests that ...
Towards a new classification of the Arthoniales (Ascomycota) based on a three-gene phylogeny focussing on the genus Opegrapha Meise Botanic Garden KU Leuven
A multi-locus phylogenetic study of the order Arthoniales is presented here using the nuclear ribosomal large subunit (nuLSU), the second largest subunit of RNA polymerase II (RPB2) and the mitochondrial ribosomal small subunit (mtSSU). These genes were sequenced from 43 specimens or culture isolates representing 33 species from this order, 16 of which were from the second largest genus, Opegrapha. With the inclusion of sequences from ...
Moderated Test Statistics to Detect Differential Deuteration in Hydrogen/Deuterium Exchange Mass Spectrometry Experiments Hasselt University KU Leuven
With differential hydrogen/deuterium exchange, differences in the structure and dynamics of protein states can be studied. Detecting statistically significant differentially deuterated peptides is crucial to draw meaningful conclusions about the distinct conformations and dynamics of the protein under study. Here, we introduced a linear model in combination with an empirical Bayes approach to detect differentially deuterated peptides. Using a ...