Publications
AI/ML Models to Predict the Severity of Drug-Induced Liver Injury for Small Molecules Vrije Universiteit Brussel
Drug-induced liver injury (DILI), believed to be a multifactorial toxicity, has been a leading cause of attrition of small molecules during discovery, clinical development, and postmarketing. Identification of DILI risk early reduces the costs and cycle times associated with drug development. In recent years, several groups have reported predictive models that use physicochemical properties or in vitro and in vivo assay endpoints; however, ...
Understanding children's preference for park features that encourage physical activity Vrije Universiteit Brussel Ghent University
BACKGROUND: Parks are a key setting for physical activity for children. However, little is known about which park features children prefer and which features are most likely to encourage them to be active in parks. This study examined the relative importance of park features among children for influencing their choice of park for engaging in park-based physical activity.
METHODS: Children (n = 252; 8-12 years, 42% male) attending ...
Multi-factorial age estimation: A Bayesian approach combining dental and skeletal magnetic resonance imaging Hasselt University KU Leuven Ghent University
"Which physical and social environmental factors are most important for adolescents' cycling for transport? An experimental study using manipulated photographs" Vrije Universiteit Brussel Ghent University
Background: Ecological models emphasize that cycling for transport is determined by an interplay between individual, physical and social environmental factors. The current study investigated (a) which physical and social environmental factors determine adolescents' preferences towards cycling for transport and (b) which individual, physical and social environmental factors are associated with their intention to actually cycle for transport. ...
A maximum difference scaling survey of barriers to intensive combination treatment strategies with glucocorticoids in early rheumatoid arthritis Vrije Universiteit Brussel KU Leuven
The objectives of the study were to determine the relative importance of barriers related to the provision of intensive combination treatment strategies with glucocorticoids (ICTS-GCs) in early rheumatoid arthritis (ERA) from the rheumatologists' perspective and to explore the relation between rheumatologists' characteristics and importance scores. A maximum difference scaling (MDS) survey was administered to 66 rheumatologists in Flanders ...
Vagally-mediated HRV as a marker of trait rumination in healthy individuals? Vrije Universiteit Brussel
The tendency to ruminate (i.e., repetitive, self-referential, negative thoughts) is a maladaptive form of emotional regulation and represents a transdiagnostic vulnerability factor for stress-related psychopathology. Vagally-mediated heart rate variability (vmHRV) provides a non-invasive, surrogate measure of vagal modulation of the heart, and higher HRV is considered an indicator of susceptibility, or ability to respond to stress. Past ...
The impact of high versus standard enteral protein provision on functional recovery following intensive care admission Vrije Universiteit Brussel Hasselt University
BACKGROUND: The PRECISe trial is a pragmatic, multicenter randomized controlled trial that evaluates the effect of high versus standard enteral protein provision on functional recovery in adult, mechanically ventilated critically ill patients. The current protocol presents the rationale and analysis plan for an evaluation of the primary and secondary outcomes under the Bayesian framework, with an emphasis on clinically important effect ...
Phylogeographic analysis of dengue virus serotype 1 and cosmopolitan serotype 2 in Africa Institute of Tropical Medicine University of Antwerp
OBJECTIVES: The origin and spread of dengue virus (DENV) circulating in Africa remain poorly characterized, with African sequences representing <1% of global sequence data.
METHODS: Whole genome sequencing was performed on serum samples (n = 29) from an undifferentiated fever study in 2016 in the Democratic Republic of Congo (DRC), and from febrile travelers returning from Africa. The evolutionary history of the newly acquired ...
Risk mapping of highly pathogenic avian influenza H5 during 2012-2017 in Taiwan with spatial bayesian modelling: implications for surveillance and control policies Institute of Tropical Medicine
During 2012-2017, a total of 1,144 highly pathogenic avian influenza (HPAI) H5 outbreaks were reported in Taiwan. We conjectured the current 3-km radius of the post-outbreak containment policy could fail to effectively alleviate the current ongoing epidemics of HPAI H5 in Taiwan. The high intensity of localized transmission of HPAI H5 at certain focal hotspots was identified to follow the spatial distribution of poultry-raising locations ...