An integrated molecular, functional and structural characterization of the determinants, underlying the multi-domain complexes between IP3 receptors and anti-apoptotic Bcl-2 and Bcl-Xl proteins KU Leuven
Intracellular Ca2+ signals play a critical role in multiple cellular processes, including proliferation and apoptosis. A key regulator of Ca2+–signaling is the inositol 1, 4, 5 trisphosphate (IP3) receptor (IP3R), which is the main intracellular Ca2+–release channel. The anti-apoptotic members of the B-cell lymphoma 2 (Bcl-2) family of proteins, Bcl-2 and Bcl-Xl, have emerged as distinct factors that critically control IP3R activity. Bcl-2 ...