Projects
EEG Connectivity-based Biomarkers of Stroke Recovery KU Leuven
NEMESIS project (Novel Effect biomarkers for MEtabolic disruptorS: evidence on health Impacts to science and policy NeedS) Hasselt University
Towards mechanistic biomarkers for amyotrophic lateral sclerosis KU Leuven
Amyotrophic lateral sclerosis is a neurodegenerative disorder affecting the motor system. Degeneration of motor neurons in the motor cortex, the brainstem and the spinal cords results in progressive muscle weakness and wasting. The median survival of ALS patients in only 3 years after disease onset, mostly due to respiratory muscle weakness leading to respiratory failure. The clinical disease presentation and the disease progression of ALS is ...
specific biomarkers to develop targeted delivery of therapeutic mRNA in various tumors using biomimetic nanomaterials KU Leuven
The main aim of this project lies in the development of a novel range of nanoformulations based on biomimicry in order to obtain a better delivery of therapeutic nanomaterials to solid tumors, enhancing therapeutic efficacy and reducing unwanted side-effects. A highly multidisciplinary research project has been set up to reach this goal, using classical, FDA-approved solid lipid nanoparticles (sLNPs), which will be coated with different cell ...
Variability reduction in MRI biomarkers of ageing and dementia Ghent University
At higher risk for pre-eclampsia following assisted reproduction: in search for biomarkers in the preconceptional endometrium of patients with polycystic ovary syndrome Vrije Universiteit Brussel
Exploring Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease (COPD) and Developing Biomarkers for Targeted Interventions: A Two-Part Investigation. KU Leuven
Skeletal muscle dysfunction is an important problem in individuals with Chronic Obstructive Pulmonary Disease (COPD). The dysfunction is not directly related to the impairment in lung function, but is nevertheless severely disabling patients. The main factors contributing to its development are not well understood. Furthermore it is unclear whether the presence of more pronounced skeletal muscle dysfunction may favor specific treatment ...
Molecular characterization of rare lymphomas to uncover new biomarkers and treatment targets. KU Leuven
During the last decades our knowledge on tumorigenesis has markedly increased due to the incorporation of next generation sequencing studies, as illustrated by improved molecular classification of tumors in general and lymphomas in particular and to the development of specific targeted therapies. However, pathogenic mechanisms have been studied less intensively in more rare lymphoma subtypes. In our research project we aim to obtain more ...
Mapping ductal carcinoma in situ in space and time to reveal biomarkers that can predict invasive risk KU Leuven
My project aims to identify and verify markers to predict whether DCIS will progress into IBC or remain harmless during a women's lifetime. Based on our preliminary data, I hypothesize that 3D DCIS growth patterns (GP) can serve as a marker for DCIS progression. Using a novel set of DCIS-PDX models combined with optical barcoding and intravital imaging technologies, I will follow the growth of DCIS lesions. From these spatiotemporal images of ...