Unraveling the role of mechanical cross-talk in the bone-cartilage unit in degenerative joint disease: an in silico multi-scale adaptive modeling approach KU Leuven
Osteoarthritis (OA) is a disease of the whole joint, with a progressive deterioration of cartilage and subchondral bone. Altered mechanical loading is widely accepted, but poorly understood as a driver of OA. Bone and cartilage are mechano-adaptive tissues. It has been assumed that changes in structural and material properties in either tissue caused by altered load distribution, drive mechano-adaptive response adaptations in the other ...