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Computational strategies and challenges for using native ion mobility mass spectrometry in biophysics and structural biology University of Antwerp
Native mass spectrometry (MS) allows the interrogation of structural aspects of macromolecules in the gas phase, under the premise of having initially maintained their solution-phase noncovalent interactions intact. In the more than 25 years since the first reports, the utility of native MS has become well established in the structural biology community. The experimental and technological advances during this time have been rapid, resulting in ...
Statistical biophysics of hematopoiesis and growing cell populations Vrije Universiteit Brussel
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Biophysics and Physiology of the Volume-Regulated Anion Channel (VRAC)/Volume-Sensitive Outwardly Rectifying Anion Channel (VSOR) KU Leuven
The volume-regulated anion channel (VRAC), also known as the volume-sensitive outwardly rectifying (VSOR) anion channel or the volume-sensitive organic osmolyte/anion channel (VSOAC), is essential for cell volume regulation after swelling in most vertebrate cell types studied to date. In addition to its role in cell volume homeostasis, VRAC has been implicated in numerous other physiological and pathophysiological processes, including cancer, ...
Materials science and biophysics applications at the ISOLDE radioactive ion beam facility KU Leuven
The ISOLDE isotope separator facility at CERN provides a variety of radioactive ion beams, currently more than 800 different isotopes from ∼70 chemical elements. The radioisotopes are produced on-line by nuclear reactions from a 1.4 GeV proton beam with various types of targets, outdiffusion of the reaction products and, if possible, chemically selective ionisation, followed by 60 kV acceleration and mass separation. While ISOLDE is mainly used ...
Updated common biophysical criteria to define natural constraints for agriculture in Europe: Definition and scientific justification for the common biophysical criteria and Technical Factsheets KU Leuven
A panel of soil, climate and land evaluation experts reviewed a set of land evaluation methods in order to elaborate an approach which can support the identification of severe natural constraints to agriculture in the EU28. The driver for this exercise is Article 50.3 of EC-Regulation 1698/2005 calling for the revision of the existing system based on criteria related to low soil productivity and poor climate conditions for agriculture and the ...
Drug transport modeling in solid tumors : a computational exploration of spatial heterogeneity of biophysical properties Ghent University
Inadequate uptake of therapeutic agents by tumor cells is still a major barrier in clinical cancer therapy. Mathematical modeling is a powerful tool to describe and investigate the transport phenomena involved. However, current models for interstitial flow and drug delivery in solid tumors have not yet embedded the existing heterogeneity of tumor biomechanical properties. The purpose of this study is to introduce a novel and more realistic ...
Development of a biophysical screening model for gestational hypertensive diseases Hasselt University
BackgroundTo investigate the possibility of using maternal biophysical parameters only in screening for the different types of gestational hypertensive diseases.MethodsA total of 969 pregnant women were randomly screened in first and second trimester, of which 8 developed Early-onset Preeclampsia, 29 Late-onset Preeclampsia, 35 Gestational Hypertension and 897 women had a normal outcome. An observational maternal hemodynamics assessment was done ...
Improving evapotranspiration in a land surface model using biophysical variables derived from MSG/SEVIRI satellite Vrije Universiteit Brussel
no abstract