cGMP signal transduction in microvascular endothelial cells of the pressure overloaded and dysfunctional heart. KU Leuven
High blood pressure is a global problem. Untreated, it leads to decreased function of the heart muscle or heart failure with serious consequences for human health and survival. This is one of the reasons why cardiovascular disease remains the leading cause of death worldwide. Failure of our current therapies emphasizes the need for a better understanding of the mechanisms in the evolution of the disease. There are several factors that play a ...