Projects
Optimization of an innovative approach to eliminate CD70-positive cancer-associated fibroblasts to improve first-line chemotherapy in advanced colorectal cancer. University of Antwerp
The P5 Type ATPase Atp13A2, a Parkinson associated gene, coordinates key trafficking mechanisms involved in the maintenance of cancer cell proteostasis KU Leuven
ATP13A2 (also called PARK9), is a transmembrane endo-/lysosomal-associated P5-type transport ATPase. Loss-of-function mutations in ATP13A2 result in the Kufor-Rakeb Syndrome (KRS), a form of autosomal Parkinson’s disease (PD). In spite of a growing interest in ATP13A2, very little is known about its physiological role in stressed cells. Recent studies suggest that the N terminal domain of ATP13A2 may hold key regulatory functions, but their ...
Improved FAP-radiotheranostics for personalized cancer treatment. University of Antwerp
Rationally designed drug combination screen in more physiologically relevant in vitro organoid models: can we improve personalised therapy for pancreatic cancer? University of Antwerp
Targeting Polo-like kinase 1 for treatment of NSCLC patients: focus on the induction of cellular senescence, the TP53 status and hypoxia. University of Antwerp
Increasing the value proposition of the IOF programs CRISParray and Amalus: CRISPRi-based target deconvolution of fibroblast modulators Ghent University
his application directly relates to two IOF programs: (i) Amalus, which develops unique small molecule therapeutics targeting fibroblasts, and (ii) CRISParray, which proposes a highly comprehensive CRISPRi screening for target deconvolution, a technology not available elsewhere.
VCs regard the Amalus program as highly valuable, but the trigger for VC investment in the Amalus program will be target deconvolution. At the same time, ...
Biopharmaceutical optimization of PET-diagnostic tools targeting fibroblast activation protein (FAP). University of Antwerp
SONO Support Center policy-oriented educational research Ghent University
PISA 2018 (years of operation from 2016 to 2020) _Werkingsjaar 2016 Ghent University
The abstract for "PISA 2018" is missing. Please contact the promotor for more information.