Understanding tumour-immune interactions and cancer immunotherapy responses from differential immune selection pressures in the cancer genome Ghent University
The human immune system has a key role in preventing tumour formation. This long-standing immunosurveillance theory has been reinforced in recent years due to the success of cancer therapies that modulate the immune system (immunotherapy). Cancer cell immune recognition is mainly mediated by neoantigens, small mutated peptides that are presented to immune cells at the cancer cell membrane via the Major Histocompatibility Complex type I ...