Coevolution of epithelium in colorectal cancer: comprehensive characterization of progress-associated tumor heterogeneity in the colorectal cancer KU Leuven
To understand the characteristics of colorectal cancer (CRC), diverse molecular classifiers have been generated. But these only capture the characteristics of the tumor at a specific stage or in a specific section. CRC has continuously evolving entities, with a complex adenoma-carcinoma sequence and later carcinoma-metastasis sequence, in a continuous coevolutionary crosstalk with the tumor microenvironment. Our past work has shown ...