Validation of new blood-brain barrier passing ferroptosis inhibitor. University of Antwerp
The detrimental role of iron in organ damage and neurodegenerative processes has been known for decades. Recently, an iron-catalyzed type of cell death was conceptualized as ferroptosis or ''biological rust''. This mode of cell death is characterized by the generation of redox-active iron that promotes excessive lipid peroxidation of the cell membrane followed by leakage of the cellular content and eventually cell death. Ferroptosis has a high ...