Projects
A multi-disciplinary approach to exploit pro-apoptotic Ca2+ signaling as a novel anti-cancer strategy. KU Leuven
Exploiting the BH4 domain of Bcl-2 as a novel target for the development of peptidomimetics that promote pro-apoptotic Ca2+ signaling. KU Leuven
Exploiting Ca2+ signaling and altered IP3R function in Bcell lymphomas KU Leuven
Cancer cells have developed different strategies to escape their cell death fate by imposing blocks in their apoptotic cell-death pathway or increasing pro-survival mechanisms. Such mechanisms make them very resistant and make cancer hard to cure. Here, we will focus on cancers depending on high levels of anti-apoptotic Bcl-2, like diffuse large B-cell lymphoma and chronic lymphocytic leukemia. Recently, experiments in healthy cells ...
Profiling of pro-apoptotic Ca2+ signaling in cancer cells. KU Leuven
The role of Ca2+ signaling for cyst formation in autosomal dominant polycystic kidney disease KU Leuven
Mutations in the genes encoding the polycystin-1 and -2 proteins lead to autosomal polycystic kidney disease (ADPKD), the most common inherited nephropathy leading to renal failure. The molecular mechanisms underlying the formation of renal cysts are poorly characterized, although better knowledge of these mechanisms could have important therapeutic consequences. Loss-of-function of polycystin-1 and -2 result in the activation of several ...
Deciphering the network that links nutrient signaling in yeast with growth potential, pH and Ca2+ homeostasis, ageing and lifespan, resistance and virulence. KU Leuven
Characterisation of auxin-induced Ca2+ signaling via chemical genetics Ghent University
Auxin is one of the most important regulators of plant development. Recently, we found that calcium plays an important rol in the regulation of auxin tranport. Here, we will screen a chemical library for inhibitors of auxin-induced Ca2+ signaling. Through the analysis and characterisation of such molecules and their targets, we aim to unravel the underlying molecular mechanism
Deciphering the network that links nutrient signaling in yeast with growth potential, pH and Ca2+ homeostasis, ageing and lifespan, resistance and virulence. KU Leuven
Cells of all living organisms are equipped with complex signal transduction networks enabling to make appropriate changes in metabolism in response to environmental changes. In this project, our focus is on how several signaling pathways in brewer’s yeast and pathogenic fungi integrate to control traits like stress resistance, reserve carbohydrate metabolism, lipid metabolism, ageing and lifespan, drug tolerance and, in case of pathogenic ...