Projects
The high- throughput identification and validation of epigenetic biomarkers for cardiovascular disease. Ghent University
In the Western World, cardiovascular diseases (CVD) represent the most important cause of death. The interaction between aging, genetics and lifestyle in the development of CVD pints towards an epigenetic component. Therefore, a high- throughput epigenetic profiling of CVD will be performed, based on samples from the longitudinal Asklepios study. This may deepen the understanding of the molecular pathology of CVD
Nanoparticle-based targeted delivery of therapeutics against arterial media calcification, a major cardiovascular complication in elderly and patients with chronic kidney disease, diabetes and osteoporosis. University of Antwerp
The role of autophagy in the prevention of oxidative stress and cardiovascular disease by olive polyphenols. University of Antwerp
The role of elastin-derived peptides in the progression of arterial stiffness and cardiovascular disease with a focus on autophagy inhibition as contributing mechanism. University of Antwerp
The role of elastin-derived peptides in the progression of arterial stiffness and cardiovascular disease with a focus on autophagy inhibition as contributing mechanism. University of Antwerp
Cardiovascular disease and cancer are linked through the NRG1/ERBB3 signaling system. University of Antwerp
Use of Microorganisms for Carotenoids Delivery: Next Generation of Probiotics for Cardiovascular Disease Ghent University
CARODEL aims to valorise the result from the previous FP7 COLORSPORE, project, in which initial isolation and characterization work was performed on Bacillus strains producing gastric-stable carotenolds. As the stability in the gastrointestinal Iract (GIT), antioxidant activity and biosavailability of particular Bacillus carotenoids was shown to be higher than those of common dietary carotenoids, the conclusions from COLORSPORE provided ...
Improving non-invasive diagnostics of cardiovascular disease using ultrasound: development of new blood flow and vessel wall quantification techniques using multiphysics modeling and in-vivo validation studies. Ghent University
Vascular applications of medical ultrasound still show severe limitations. A multiphysical simulation tool was previously developed to support the development of new techniques. This project will use our simulationmodel to develop vascular strain imaging, a highly useful tool when screening for vulnerable arterial lesions (e.g. plaques). Both conventional and new imaging approaches will be explored using human and murine data.