Projects
Genetic and mtDNA contributions to early cardiovascular ageing and disease: a population study KU Leuven
Heart failure (HF) is a progressive disorder that begins with cardiovascular risk factors, proceeds to asymptomatic maladaptive left ventricular (LV) remodelling and dysfunction, and then evolves into clinically overt HF and disability. The genetic and molecular drivers that underlie progressive cardiac dysfunction and remodelling are only partially understood.
The progression of LV dysfunction is associated with changes in cardiac ...
Elucidating the contribution of NAFLD (non-alcoholic fatty liver disease) and insulin resistance in the development of cardiovascular complications in people with type 1 diabetes. University of Antwerp
Mitochondrial DNA content in cardiovascular ageing and disease: a population study. KU Leuven
A major burden of modern society is the progressive increase in age-associated diseases such as heart failure (HF). The genetic and environmental drivers of left ventricular (LV) dysfunction progression remain to be elucidated. LV dysfunction is associated with changes in cardiac energy metabolism. Mitochondria play a central role in a variety of cardiac cell functions. The mitochondrial DNA (mtDNA) content correlates with the size and number ...
Mitochondrial DNA content in cardiovascular ageing and disease: a population study Hasselt University
From hit to lead: inducing basal autophagy for treating cardiovascular diseases. University of Antwerp
Joint Action on Cardiovascular Diseases and Diabetes (JACARDI). University of Antwerp
RADical reduction of OXidative stress in cardiovascular diseases. KU Leuven
Cardiovascular disease (CVD) constitutes a major and increasing health burden in developed countries. The prediction is that the prevalence of these conditions will increase by ~60% over the next 20 years. Therefore, the development of novel treatments for patients with CVD becomes more and more urgent. Oxidative stress is an important molecular contributor to the pathogenesis of CVD. However, oxidative stress-related therapeutic strategies ...
How do cardiovascular diseases and their treatments affect the microstructural-mechanical relationship? An advanced 3D microstructural analysis & modeling approach KU Leuven
Cardiovascular diseases are still the leading cause of death worldwide. Treatment options such as intravascular stent deposition or balloon angioplasty often tend to fail. The hypothesis is that this failure is partly due the application of too large mechanical forces on the vascular tissue during treatment. However, the exact mechanisms are not yet fully understood. To better understand these mechanisms and to evaluate potential new ...
Thromboinflammation in Cardiovascular Diseases KU Leuven
Our blood clotting system protects us from bleeding, and is crucial for survival. On the other hand, undesired activation of blood clotting is the most important cause of death. Indeed, when blood clots form inside the blood vessels, it can cause heart infarcts, stroke, or obstruction of the lung blood vessels.
Luckily, we have effective drugs that prevent blood clotting. These drugs are used to prevent deaths and disability in ...