Projects
Production of next generation modulators of pannexins and connexins as novel therapeutics in the treatment of inflammatory cardiovascular, hepatic and joint diseases. Vrije Universiteit Brussel
Activation of the contact pathway of coagulation in cardiovascular diseases. KU Leuven
Our blood clotting system protects us from bleeding, and is crucial for survival. On the other hand, undesired activation of blood clotting is the most important cause of death. Indeed, when blood clots form inside the blood vessels, it can cause heart infarcts, stroke, or obstruction of the lung blood vessels.
Luckily, we have effective drugs that prevent blood clotting. These drugs are used to prevent deaths and disability in millions ...
JACARDI Joint Action on CARdiovascular Diseases and DIabetes KU Leuven
The JACARDI project aligns with the objectives of the European Union Health Programme (EU4H) by focusing on the reduction of NCDs at both individual and societal levels. It seeks to reduce the burden of CVD and DM while increasing awareness of related risks and the acceptance of innovative lifestyle interventions.
The project’s relevance extends to addressing the diverse needs of the people in Europe, harmonizing health systems, and ...
Fonds Baillet Latour Grant for Medical research in Belgium - 2019 - Cardiovascular diseases Ghent University
High-throughput DNA-methylation profiling of cardiovascular diseases Ghent University
In light of the enormous impact of cardiovascular diseases (CVD) and clear indications for epigenetic effects, this project aims at the high-throughput identification of DNA-methylation markers involved in atherosclerosis, the principal cause of CVD. Herefore, a combination of ChIP, next-generation sequencing and high-throughput qPCR will be applied, supported by an apporopriate data-analysis, based on samples of the Asklepios study.
Non-invasive optical measurement and physical modelling of blood pulse wave velocity for early detection of cardiovascular diseases. University of Antwerp
Activation of the contact pathway of coagulation in cardiovascular diseases KU Leuven
New strategies of soluble guanylyl cyclase (sGC) activation and their potential role in the treatment of cardiovascular diseases and erectile dysfunction Ghent University
sGC is a cardinal enzyme in the maintenance of blood pressure and for eliciting erection. NO released from endothelial cells and NANC neurons is the main activator. Recently designed drugs that directly stimulate sGC independent of NO or that stimulate sGC through generation of CO are of potential clinical interest. The project aims ro discover the basic mechanism of action of these drugs.