Projects
Preparations of an early-phase clinical trial with CAR-NK cells for patients with acute myeloid leukaemia. University of Antwerp
SRP-Onderzoekszwaartepunt: Platform for Clinical Trial Network to Prevent and Cure Type 1 Diabetes Vrije Universiteit Brussel
ClinicalTrials.COV : Clinical long term-follow up of COVID-19 patients that underwent immuneintervention clinical trials or standard of care. Ghent University
The Department of Respiratory Medicine at UZ Gent has already admitted 134 COVID-19 patients with severe lung damage, hypoxia and cytokine storm. These were randomized in two newly designed immune intervention trials (COV-AID and SARPAC). This BOF grant will be used to pay for data managers and clinical follow up to study if these patients develop fibrosis and do better when they received immunointervention.
Chromatography for the purification of in vitro transcribed RNA as part of the production process of lipid nanoparticle vaccines and cancer immunotherapeutics for use in clinical trials (C-puRNA) Ghent University
The Cell and Gene therapy unit UZ Gent produces drugs based on cells and/or DNA/RNA for clinical trials. Recently, we focused on the development of the production process of RNA vaccines and RNA-based immunotherapeutics for cancer. We have an academic project in collaboration with the department of Pharmacy and Medical Genetics of the UGent, and VIB, as well as commercial collaborations. For the robust production of RNA-based medicinal ...
Incontinence- Associated Dermatitis: Pathophysiological and histopathological research, development and validation of a core set for outcome reporting in IAD clinical trials, and an RCT to test a 3-in-1 protocol for IAD prevention. Ghent University
IAD is a type of irritant contact dermatitis caused by incontinence. The etiology is complex, the pathophysiology and histopathology are largely understudied. There is limited knowledge about prevention and treatment. The objectives are (1) to study the pathophysiology and histopathology, (2) to develop a core set for outcome reporting, and (3) to perform a RCT and health economic analysis for IAD prevention.
Which exercises to prescribe in patients with subacromial pain? A multi-center randomized controlled trial. University of Antwerp
Effects of continual oxytocin treatment on core social symptoms in children with autism with and without comorbid intellectual disability: A verification trial with long-term follow-up KU Leuven
The effect of extended heart failure Audit and Feedback on cardiovascular hospitalizations in general practice: a randomized controlled trial KU Leuven
Differential Efficacy of Pre-structured and Explorative Psychodynamic Interventions in Dependent and Selfcritical Depressive Patients: A Randomized Controlled Trial. Ghent University
Efficacy research shows substantial between--subject variability in the efficacy of different types of psychodynamic therapy for depression. Post-hoc analyses of naturalistic data suggest that pre-structured interventions are more effective for dependent depressive patients while explorative interventions are more effective for self-critical patients. This project proposes a randomized controlled trial in which these findings are tested in an ...