Projects
Movement characteristics to identify the risk of relapse in children with clubfoot KU Leuven
The clubfoot deformity is one of the most common congenital orthopaedic “conditions” . Worldwide approximately 100,000 children are born with unilateral or bilateral clubfoot every year. Nowadays, the Ponseti method is worldwide the golden standard for the initial treatment of the clubfoot. Despite the large body of literature available on good initial outcomes of the Ponseti method, far less is known about the functional long-term outcome of ...
Taking function and participation into account in the treatment of children with clubfoot KU Leuven
The overall aim of this research project is to increse insight in the participation level, motor ability and function in children with clubfoot to come to a better mutidisciplinary treatment for this population. To gain these insights, we will conduct three studies.
The aim of the first study is to determine the level of participation in daily activities in children with clubfoot and if this level of participation is associated with ...
Downstream targets of the metabolic stress sensor SnRK1 - One kinase to rule them all KU Leuven
The evolutionarily conserved SnRK1 (SNF1-related kinase 1) protein kinase (the ortholog of yeast SNF1 and mammalian AMPK) is a major metabolic sensor, allowing acclimatization and energy homeostasis upon changes in energy availability, thereby ensuring plant survival. SnRK1 is activated by low energy stress and repressed by high photosynthetic sugar levels, with the allosteric inhibitor trehalose-6-P acting as a proxy for sucrose supply. To ...
The role of plantar flexor muscles in ankle power of clubfeet patients KU Leuven
Congenital clubfoot is a complex deformity in which several abnormalities of the foot are present. Left untreated the clubfoot leads to deformity, functional disability and pain. Initial treatment of the clubfoot is currently done according to the Ponseti method. Even though good initial correction of the clubfoot is often achieved with the Ponseti method, some patients show a reoccurrence of the original clubfoot, also referred to as a ...
An improved detection and treatment of relapse clubfeet. KU Leuven
With the aid of extensive aisle analyzes, this study will provide a better insight into the factors that are linked to relapse clubfoot and also allow an early detection of that relapse.