Publications

Introduction

The subthalamic nucleus (STN) is considered an important modulator in the basal ganglia. Together with the striatum, the STN forms the main input region in the motorloop circuitry [1]. It is composed of glutamatergic neurons that participate in the so called indirect pathway, projecting towards the output nuclei of the basal ganglia [substantia nigra (SN) pars reticulata and the entopeduncular nucleus] and the globus ...

Introduction: Compound 21 (C21) is a non-peptide angiotensin II type 2 (AT2) receptor agonist. It is used to study the role of the AT2 receptor in dopamine release and synthesis in the striatum and to study its possible neuroprotective effects in animal models of Parkinson's disease [1, 2]. In literature, there is no data available on the blood brain barrier (BBB) passage of this compound. In order to investigate its blood brain passage, a ...

Introduction:

Mutations in the mitochondrial phosphatase and tensine homologue-induced kinase 1 (PINK-1) cause
autosomal recessive early-onset Parkinson's disease (PD). PINK-1 is a protein kinase with a
mitochondrial signal sequence and confers protective effects to mitochondria, where it is primarily
located. How PINK-1 causes dopaminergic dysfunction and degeneration in PD patients is unknown.
PINK-1 protects ...

Four cases previously treated with ipilimumab with a total of six histologically confirmed symptomatic lesions of RNB without any sign of active tumour following stereotactic irradiation of MBM are reported. These lesions were all originally thought to be disease recurrence. In two cases, ipilimumab was given prior to SRT; in the other two ipilimumab was given after SRT. The average time from first ipilimumab to RNB was 15 months. The average ...

Introduction
Neuropeptides are an important and diverse class of neuronal signalling molecules. They seem to play an important role when the central nervous system is challenged, as during epileptic seizures [1,2]. In order to further characterise the neuropeptides involved in the physiopathology of epilepsy, it is essential to monitor their concentration dynamics in the brain. Quantification of neuropeptides in dialysates is challenging ...

The response of n(+)p silicon strip sensors to electrons from a Sr-90 source was measured using a multi-channel read-out system with 25 ns sampling time. The measurements were performed over a period of several weeks, during which the operating conditions were varied. The sensors were fabricated by Hamamatsu Photonics on 200 im thick float-zone and magnetic-Czochralski silicon. Their pitch was 80 ifm, and both p-stop and p-spray isolation of the ...

PurposeMuch of the management research on socially responsible investment (SRI) consists in demonstrating how SRI is good for business and good for society. But the belief that business and market-based strategies will bring positive social and ecological change is far from natural and results in disputes. This study shows how SRI proponents have to develop and combine arguments in order to construct and defend a valid and plausible discourse on ...

To explore biochemical events in the brain, microdialysis is the pre-eminent in vivo sampling technique, enabling the collection of small, hydrophilic endogenous compounds. This tool is applied for neuropharmacological research in rodent models to study the release of different neurotransmitters such as the monoamines dopamine, noradrenaline and serotonin in specific brain areas [1].

The simultaneous determination of the monoamine ...

To explore biochemical events in the brain, microdialysis is the pre-eminent in vivo sampling technique, enabling the collection of small, hydrophilic endogenous compounds. This tool is applied for neuropharmacological research in rodent models to study the release of different neurotransmitters such as the monoamines dopamine, noradrenaline and serotonin in specific brain areas [1].

The simultaneous determination of the monoamine ...