Publications
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Glutamate – dopamine interactions in the subthalamic nucleus. (Oral) Vrije Universiteit Brussel
Introduction
The subthalamic nucleus (STN) is considered an important modulator in the basal ganglia. Together with the striatum, the STN forms the main input region in the motorloop circuitry [1]. It is composed of glutamatergic neurons that participate in the so called indirect pathway, projecting towards the output nuclei of the basal ganglia [substantia nigra (SN) pars reticulata and the entopeduncular nucleus] and the globus ...
The subthalamic nucleus (STN) is considered an important modulator in the basal ganglia. Together with the striatum, the STN forms the main input region in the motorloop circuitry [1]. It is composed of glutamatergic neurons that participate in the so called indirect pathway, projecting towards the output nuclei of the basal ganglia [substantia nigra (SN) pars reticulata and the entopeduncular nucleus] and the globus ...
Microbore LC with UV detection to study the in vivo passage of Compound 21, a non-peptidergic AT2 receptor agonist, to the striatum. Vrije Universiteit Brussel
Introduction: Compound 21 (C21) is a non-peptide angiotensin II type 2 (AT2) receptor agonist. It is used to study the role of the AT2 receptor in dopamine release and synthesis in the striatum and to study its possible neuroprotective effects in animal models of Parkinson's disease [1, 2]. In literature, there is no data available on the blood brain barrier (BBB) passage of this compound. In order to investigate its blood brain passage, a ...
Susceptibility of PINK-1 deficient mice to 6-OHDA induced oxidative stress determined with in vivo salicylate trapping Vrije Universiteit Brussel
Introduction:
Mutations in the mitochondrial phosphatase and tensine homologue-induced kinase 1 (PINK-1) cause
autosomal recessive early-onset Parkinson's disease (PD). PINK-1 is a protein kinase with a
mitochondrial signal sequence and confers protective effects to mitochondria, where it is primarily
located. How PINK-1 causes dopaminergic dysfunction and degeneration in PD patients is unknown.
PINK-1 ...
Mutations in the mitochondrial phosphatase and tensine homologue-induced kinase 1 (PINK-1) cause
autosomal recessive early-onset Parkinson's disease (PD). PINK-1 is a protein kinase with a
mitochondrial signal sequence and confers protective effects to mitochondria, where it is primarily
located. How PINK-1 causes dopaminergic dysfunction and degeneration in PD patients is unknown.
PINK-1 ...
Symptomatic Histologically Proven Necrosis of Brain following Stereotactic Radiation and Ipilimumab in Six Lesions in Four Melanoma Patients Vrije Universiteit Brussel
Four cases previously treated with ipilimumab with a total of six histologically confirmed symptomatic lesions of RNB without any sign of active tumour following stereotactic irradiation of MBM are reported. These lesions were all originally thought to be disease recurrence. In two cases, ipilimumab was given prior to SRT; in the other two ipilimumab was given after SRT. The average time from first ipilimumab to RNB was 15 months. The average ...
Nano LC-MS/MS for the monitoring of hippocampal neuropeptides possibly involved in limbic epilepsy. Vrije Universiteit Brussel
Introduction
Neuropeptides are an important and diverse class of neuronal signalling molecules. They seem to play an important role when the central nervous system is challenged, as during epileptic seizures [1,2]. In order to further characterise the neuropeptides involved in the physiopathology of epilepsy, it is essential to monitor their concentration dynamics in the brain. Quantification of neuropeptides in dialysates is challenging ...
Neuropeptides are an important and diverse class of neuronal signalling molecules. They seem to play an important role when the central nervous system is challenged, as during epileptic seizures [1,2]. In order to further characterise the neuropeptides involved in the physiopathology of epilepsy, it is essential to monitor their concentration dynamics in the brain. Quantification of neuropeptides in dialysates is challenging ...
Exploring the Brain by UHPLC-ECDChallenging Analysis of Low Neurotransmitter Levels Vrije Universiteit Brussel
To explore biochemical events in the brain, microdialysis is the pre-eminent in vivo sampling technique, enabling the collection of small, hydrophilic endogenous compounds. This tool is applied for neuropharmacological research in rodent models to study the release of different neurotransmitters such as the monoamines dopamine, noradrenaline and serotonin in specific brain areas [1].
The simultaneous determination of the monoamine ...
The simultaneous determination of the monoamine ...
Exploring the Brain by UHPLC-ECD Challenging Analysis of Low Neurotransmitter Levels Vrije Universiteit Brussel
To explore biochemical events in the brain, microdialysis is the pre-eminent in vivo sampling technique, enabling the collection of small, hydrophilic endogenous compounds. This tool is applied for neuropharmacological research in rodent models to study the release of different neurotransmitters such as the monoamines dopamine, noradrenaline and serotonin in specific brain areas [1].
The simultaneous determination of the monoamine ...
The simultaneous determination of the monoamine ...
Using microdialysis to analyse the passage of monovalent nanobodies through the blood-brain barrier Vrije Universiteit Brussel Ghent University University of Antwerp
BACKGROUND AND PURPOSE: Nanobodies are promising antigen-binding moieties for molecular imaging and therapeutic purposes because of their favourable pharmacological and pharmacokinetic properties. However, the capability of monovalent nanobodies to reach targets in the CNS remains to be demonstrated.
EXPERIMENTAL APPROACH: We have assessed the blood-brain barrier permeability of Nb_An33, a nanobody against the Trypanosoma brucei ...
Acute running stimulates hippocampal dopaminergic neurotransmission in rats, but has no influence on brain-derived neurotrophic factor. Vrije Universiteit Brussel
Hippocampal brain-derived neurotrophic factor (BDNF) protein is increased with exercise in rats. Monoamines seem to play a role in the regulation of BDNF, and monoamine neurotransmission is known to increase with exercise. The purpose of this study was to examine the influence of acute exercise on monoaminergic neurotransmission and BDNF protein concentrations. Hippocampal microdialysis was performed in rats that were subjected to 60 min of ...